Pemphigus Vulgaris – Pemphigus vulgaris is a rare autoimmune disorder occurs when the immune system mistakenly attacks the upper layers of the skin. Blisters of varying sizes appear on the skin and on the lining of the mouth and other mucous membranes.
Pemphigus Vulgaris Symptoms
Treatment for Pemphigus Vulgaris
In pemphigus vulgaris, autoantibodies attack the desmosomal proteins, which connect the keratinocytes to one another. This attack results in a more severe, potentially fatal condition with fragile, flaccid blisters, usually with significant mucosal involvement. Diagnosis is made with biopsy and IF staining to identify and localize the antibodies. Management involves immunosuppression with corticosteroids and other steroid-sparing immunomodulatory agents.